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Determination of multielement concentrations in normal human organs from the Japanese

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Abstract

In order to elucidate the distribution of elements in organs from healthy Japanese, instrumental neutron activation analysis (INAA), based on the preliminary examination, was applied to quantitative determination of multielements in nine organs autopsied (brain, heart, kidney, liver, lung, muscle, pancreas, spleen, and thyroid). The following results were obtained: (1) The values obtained for each element could be considered to be representative as "normal values" and "ranges" in organs from healthy Japanese males; (2) the essential elements Br, Cl, Co, Cu, Fe, K, Mn, Na, Rb, Se, and Zn were not affected by external environmental factors or by racial difference; (3) renal and hepatic Cd levels were very high in several cases and the accumulation has still been in progress in the Japanese, whereas the contaminant elements are low in each organ except for lung.

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References

  1. W. S. Snyder, M. J. Cook, E. S. Nasset, L. R. Karhausen, G. P. Howells, and I. H. Tinpton, Report of the Task Group on Reference Man. International Commission on Radiological Protection No. 23, Pergaman Press, Oxford (1974).

    Google Scholar 

  2. E. J. Underwood, Trace Elements in Human and Animal Nutrition, Academic, New York (1977).

    Google Scholar 

  3. G. V. Iyengar, W. E. Kollmer, and H. J. M. Bowen, The Elemental Composition of Human Tissues and Body Fluids, Verlag Chemie, Weinheim (1978).

    Google Scholar 

  4. T. G. Aalbers, Cardiovascular diseases and trace elements, Durukkerij Blok en Zonen, Dieren, private communication.

  5. S. Takacs and A. Tatar, Trace elements in the environment and in human organs: analysis according to domicile and sex. Z. Gesamte Hyg. 37, 53–55 (1991).

    PubMed  CAS  Google Scholar 

  6. E. Andrasi, M. Suhajda, I. Saray, L. Bezur, L. Ernyei, and A. Reffy, Concentration of elements in human brain: glioblastoma multiforme, Sci. Total Environ. 139/140, 399–402 (1993).

    Article  Google Scholar 

  7. R. Zeisler, P. Ostapczuk, S. F. Stone, and M. Stoeppler, Effective tools for the trace element characterization of tissues: neutron activation analysis and voltammetry, Sci. Total Environ. 139/140, 403–410 (1993).

    Article  Google Scholar 

  8. T. Takeuchi, Y. Nakano, A. Aoki, S. Ohmori, and T. Tsukatani, Comparisons of elemental concentrations in hair of the inhabitants of heavy metal polluted areas with those of normal Japanese, J. Radioanal. Nucl. Chem. 112, 259–272 (1987).

    Article  CAS  Google Scholar 

  9. T. P. Cheng, J. S. Morris, S. R. Koirtyohann, V. L. Spate, and C. K. Baskett, Study of the correlation of trace elements in carpenters’ toenails, J. Radioanal. Nucl. Chem. 195, 31–42 (1995).

    Article  CAS  Google Scholar 

  10. F. A. EI-Amri and M. A. R. EI-Kabroum, Trace element concentrations in human bone using instrumental neutron activation analysis. J. Radioanal. Nucl. Chem. 217, 205–207 (1997).

    Article  Google Scholar 

  11. G. Ingrao, P. Belloni, S. D. Pietro, and G. P. Santaroni, Levels of some trace elements in selected autopsy organs, and in hair and blood samples from adult subjects of Italian population, Biol. Trace Element Res. 26–27, 699–708 (1990).

    Article  Google Scholar 

  12. J. Bacso, D. Balazs, I. Uzonyi, G. Lusztig, and I. Szigety, Study of relationships between micro element contents of human hair and other tissues in connection with environmental contamination and some diseases, Report on an IAEA Co-ordinated Research Programme, NAHRES-18, pp. 5–26 (1993).

  13. Y. D. Cheng, G. S. Zhuang, and Y. X. Zhaung, Study on correlation of trace elements in human hair and internal organs by nuclear methods, Report on an IAEA Co-ordinated Research Programme, NAHRES-18, pp. 27–50 (1993).

  14. J. Matsubara, T. Sato, and S. Ohomori, Correlation among multi-elemental concentrations in liver, kidney and hair of humans, Report on an IAEA Co-ordinated Research Programme, NAHRES-18, pp. 87–99 (1993).

  15. E. Sabbioni, C. Minoia, R. Pielna, S. Fortaner, M. Gallorini, and A. Saltelli, Trace element reference values in tissues from inhabitants of the European community, Sci. Total Environ. Res. 120, 39–62 (1992).

    Article  CAS  Google Scholar 

  16. J. Yoshinaga, H. Imai, M. Nakazawa, T. Suzuki, and M. Morita, Lack of significantly positive correlations between elemental concentrations in hair and in organs, Sci. Total Environ. 99, 125–135 (1990).

    Article  PubMed  CAS  Google Scholar 

  17. Y. Yamamoto, T. Sato, K. Mori, et al., Concentrations of trace elements in the hair, liver and kidney from autopsy subjects by neutron activation analysis, Res. Pract. Forensic Med. 34, 97–108 (1991).

    Google Scholar 

  18. Y. Katoh, T. Sato, and Y. Yamamoto, Multielemental analysis for human organs, Bull. Tokyo Metropol. Coll. Allied Med. Sci. 8, 177–185 (1995).

    Google Scholar 

  19. K. Sumino, K. Hayakawa, T. Shibata, and S. Kitamura, Heavy metals in normal Japanese tissues, Arch. Environ. Health 30, 487–494 (1975).

    PubMed  CAS  Google Scholar 

  20. M. Yukawa, M. Suzuki-Yasumoto, K. Amano, and M. Terai, Distribution of trace elements in the human body determined by neutron activation analysis, Arch. Environ. Health 35, 36–44 (1980).

    PubMed  CAS  Google Scholar 

  21. H. Teraoka, Distribution of 24 elements in the internal organs of normal males and the metallic workers in Japan, Arch. Environ. Health 36, 155–164 (1981).

    PubMed  CAS  Google Scholar 

  22. K. Nishiyama, T. Miki, S. Sakurai, et al., Distribution of trace elements in normal human organs and tissues determined by neutron activation analysis. Co-operative Research (A) 5730014 supported by Grand in Aid for Scientific Research from the Ministry of Education, Study Report (1985).

  23. Y. Katoh, T. Sato, and Y. Yamamoto, A preliminary study on determination of concentrations of multi-element in human organs using INAA, in press.

  24. T. Sato, Activation analysis of biological materials, in Activation Analysis, Z. B. Alfassi, ed., CRC, New York, Vol. II (1990).

    Google Scholar 

  25. N. I. Ward and J. A. Mason, Neutron activation analysis techniques for identifying elemental status in Alzheimer’s disease, J. Radioanal. Nucl. Chem. 113, 515–526 (1987).

    Article  CAS  Google Scholar 

  26. J. D. Stedman and N. M. Spyrou, Elemental analysis of the frontal lobe of normal brain tissue and that affected by Alzheimer’s disease, J. Radioanal. Nucl. Chem. 217, 163–166 (1997).

    Article  CAS  Google Scholar 

  27. T. G. Aalbers, J. P. W. Houtman, and B. Makkink, Trace-element concentrations in human autopsy tissue, Clin. Chem. 33(11), 2057–2064 (1987).

    PubMed  CAS  Google Scholar 

  28. Y. Wang, G. Zhuang, M. Tan, M. Zhi, and Y. Cheng, Distribution of some elements in human hair and internal organs, determined by neutron activation analysis, J. Radioanal. Nucl. Chem. 151, 301–311 (1991).

    Article  CAS  Google Scholar 

  29. L. Tandon, E. J. Kasarskis, and W. D. Ehmann, Elemental imbalance studies by INAA on extraneural tissues from amyotrophic lateral sclerosis patients, J. Radioanal. Nucl. Chem. 195, 13–19 (1995).

    Article  CAS  Google Scholar 

  30. W. J. Altaf and N. M. Spyrou, Evaluation of concentrations of major and trace elements in human lung using INAA and PIXE, J. Radioanal. Nucl. Chem. 217, 201–204 (1997).

    Article  CAS  Google Scholar 

  31. S. O. Rogero, M. Saiki, P. H. N. Saldiva, and M. L. Daliberto, Determination of trace elements in human lung samples, Biol. Trace Element Res. 43–45, 489–496 (1994).

    Article  Google Scholar 

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Authors and Affiliations

  1. Faculty of Health Sciences, Tokyo Metropolitan University of Health Sciences, Tokyo, Japan

    Yoh Katoh

  2. Tokyo Metropolitan Institute Neuroscience, Shiga University of Medical Science, Shiga, Japan

    Takeo Sato

  3. Department of Legal Medicine, Shiga University of Medical Science, Shiga, Japan

    Yoshio Yamamoto

Authors
  1. Yoh Katoh
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  2. Takeo Sato
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  3. Yoshio Yamamoto
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Katoh, Y., Sato, T. & Yamamoto, Y. Determination of multielement concentrations in normal human organs from the Japanese. Biol Trace Elem Res 90, 57–70 (2002). https://doi.org/10.1385/BTER:90:1-3:57

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  • DOI: https://doi.org/10.1385/BTER:90:1-3:57

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